Understanding Human Metabolism, Metabolites, and Recent ASEA Research Developments
ASEA Science Advisory Council Prepared by: Gary Samuelson, Ph.D. Robertson D. Ward, M.D., FAAFP David Carpenter, N.D., C.Ac., C.C.I.
The North Carolina Research Campus, and the Appalachian State University Human Performance Laboratory, under the direction of Dr. David Nieman’s world renowned team of scientists, uncovered new findings proving that the consumption of ASEA empowers humans to shift the availability of free fatty acids. These calorie sources represent a more favorable and efficient source of fuel for exercise and all daily life activity.
Facts about Our Metabolism and Sports Performance
Cells inside our body breathe! The processes of metabolism at a cellular level involves the consumption of molecular oxygen and large molecule energy sources (sugar, glycogen, fatty acids, and amino acids). Through the process of oxidative phosphorylation (cellular respiration…breathing!) the cells create energy (ATP). The mitochondria in our cells do this work, and this is where Redox Signaling molecules are created.
Metabolism and Athletes
We understand that our cells always strive to run at the greatest efficiency possible. Through the conditioning of our bodies, our cells learn to use certain fuel sources preferentially. We are all familiar with the fatigue and pain that happens after rigorously exercising out-of-shape muscle groups. This happens because the muscle exhausts the standard glycogen source for fuel and then shifts to anaerobic metabolism (using fuel without oxygen), which forms lactic acid metabolites. But trained distance runners have conditioned their bodies to utilize a different fuel source: fatty acids (which are 6 times more energy-providing than other sources). By using fatty acids, these athletes preserve their muscle glycogen stores for strenuous bursts, like at the end of races, and that means greater endurance.
This is important. Endurance athletes actually condition their bodies to use fatty acids as a preferred fuel source, sparing muscle glycogen and increasing endurance.
Specific Metabolite Research Findings with ASEA:
The astonishing results of this randomized, double-blinded, crossover, placebo-based research showed that after one week of drinking 4 ounces of ASEA daily, the test subjects demonstrated a shift in 43 of 108 metabolites measured from the blood sample. These shifts were revealed using ultra-sensitive mass-spectroscopic measurement techniques. These shifts were so great that it was thought that there might be a software anomaly and scientists requested a manual inspection to verify data.
The largest metabolite shifts were in serum fatty acids. Again, these shifts happened after one week of consumption and before any athletic activity. Fatty acids are typically mobilized from abdominal body fat stores. They included myristic acid, palmitic acid, oleic acid, stearic acid, palmitelaidic acid, and capric acid. Don’t let the “acid” part throw you off; these are sources of fuel for the human body.
The chemical markers of these fatty acids are called “metabolites,” and their various concentrations in our blood represent a fingerprint of our metabolic balance. The metabolite shifts found due to ASEA ingestion are profound and very beneficial to health, since these shifts mimic what the body does when seeking fuel efficiency; that is, using fatty acids as a preferred fuel source and sparing muscle glycogen.
These important metabolite changes have resulted in applications for new patents for ASEA, and have prompted further studies at the North Carolina Research Campus. Additionally, all of these changes occurred without any evidence of toxicity whatsoever on any basic organ functions in liver and kidney tissue.
These initial results from a larger study on athletic performance have demonstrated that ASEA, which is composed of Redox Signaling molecules, has a profound impact on mobilization of fatty acids as they aid with efficiency in cellular respiration. This favorable pattern of increased availability of fatty acids for fuel consumption represents a foundational shift in our metabolic fingerprint – a shift toward more effective patterns of fuel usage and energy output.
ASEA athletes are finding they can go farther, faster, longer without red-lining their heart rate or going into critical oxygen debt
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ASEA athletes are finding they can go farther, faster, longer without red-lining their heart rate or going into critical oxygen debt
Clinical Trial on ASEA confirms Athletic Advantage
AntonyGalvan New Research Shows Link to Drinking ASEA and Likely Glycogen Sparing for Athletes
Study finds that after drinking ASEA for one week, athletes experienced shift in 43 metabolites
ASEA, LLC has announced the release of findings at the Experimental Biology 2012 Conference in San Diego of a new study from the Human Performance Laboratory showing increased power output and endurance among competitive athletes.
The study, released April 25, 2012, supervised by Dr. David C. Nieman, DrPH, FACSM at the Human Performance Laboratory, Appalachian State University, found that after drinking ASEA athletes experienced massive free-fatty acid mobilization in the blood PRIOR to exercise to a level normally found only after heavy exercise.
“These are very significant findings,” said Nieman. “Our research demonstrated that ASEA is causing mobilization of free-fatty acids PRIOR to exercise, making this source of fuel available at the outset of exercise or competitive performance. This has important implications, especially regarding glycogen sparing, which is something every athlete tries to achieve.”
Glycogen sparing is the use of non-carbohydrates as a source of energy during exercise so that the depletion of muscle glycogen is delayed. When glycogen is spared the body burns fats for energy, making a greater contribution to an athlete’s efforts during the initial stages of a race. This leaves more glycogen for the later stages of racing or exercise, and muscle fatigue will be delayed.
The research found that after drinking ASEA for one week, athletes were experiencing a shift in 43 metabolites.
“We have rarely seen such a drastic difference. For 43 of those signals to change, that is a quarter of the metabolite profile that we are monitoring. It is a huge bump in metabolite shifts that are due to the ingestion of just one product,” said Nieman.
What do these metabolite shifts mean for athletes?
“Athletes actually started the exercise after drinking ASEA with a lot more of these free-fatty acids in their blood. The reason that is important is that the muscles will actually use that as fuel, sparing the muscle glycogen and the use of amino acids which is what we found as we analyzed the data,” said Nieman.
“Every understanding from the literature is that these probably came from the fat stores in the abdominal area,” said Nieman. “So if you drink ASEA we found that the fats go up in the blood. If you’re not exercising, those fats will still be used to support the body’s metabolism for life.”
Simply drinking ASEA for seven days mobilized fuel stores in the body from abdominal fat. For those that want to burn more fat during exercise ASEA is ideal. Even without exercise the freed up fat stores will be used by the body as fuel.
Although this is the first laboratory study of ASEA on athletes, many endurance athletes have been drinking ASEA and noticing improvements in their race times, recovery after racing/training, etc.
James Lawrence, World Record, Most Triathlons 70.3 races, said, “I’ve experienced all these tremendous benefits over the last few years when I’m doing all these world records, and maybe didn’t understand it, but was fearful to go off the product. With this new study it’s really helped me understand why I don’t get sore, and why I’m able to just lock in this strong pace and hold it for so long.”
Cody Waite, professional Xterra triathlete, had this to say about Dr. Nieman’s study. “My thoughts on the study are that I kind of already knew this through my own experience with the product. But at the same time it’s great to have that solid evidence that laboratory test make official. That gives it that official stamp of approval from the scientists and then the stamp of approval from lead athletes.”
Diana MacManus, three-time national swimming champion said, “With ASEA I’ve noticed that my times and my meets have improved significantly. Learning about the research behind ASEA boosts my confidence and reinforces what I already know.”
Typically, muscle glycogen is reduced in the body during a single or many groups of energy expenditures. For example, during a single sprint muscle glycogen may deplete by 25% to 30% of the resting levels. Similarly, at the end of longer durations (60 to 90 minutes) of high, moderate and low exercise muscle, glycogen will be dramatically reduced or depleted.
The study included 20 fit athletes in a randomized, double-blind, placebo-based, cross-over study. After baseline testing for VO2Max and body composition, one-half of the athletes drank four ounces of ASEA each day for seven days. The other one-half of the athletes drank four ounces of a placebo for seven days. Then all athletes completed a 75-km cycling trial, with blood drawn prior to the trial, immediately after the trial and one hour after the trial.
After a “washout” period in which none of the athletes drank ASEA or the placebo, a seven day cross-over study was conducted. The original ASEA group drank the placebo and the original placebo group drank ASEA for a seven day period. Then all athletes completed a second 75-km cycling trial, with blood drawn prior to the trial, immediately after the trial and one hour after the trial.
The research demonstrated that drinking ASEA taps into the body’s largest energy reserves, freeing fatty acids from adipose tissue, BEFORE exercise or athletic competition.
“This unexpected mobilization of fatty acids in theory will lead to better endurance in athletes, assisting athletes to maintain a certain pace for longer periods of time,” said Nieman.
The research found that the release of fatty acids is coming from fatty adipose tissue, the body’s source of abundant, available energy. Adipose tissue is fat stored around the organs of the body, with the most common and largest fat store being the abdominal area. Adipose tissue triglycerides represent the largest energy reserve in the human body. Utilizing these stores is critical for prolonged endurance exercise.
The study also demonstrated that the athletes in the study experienced a massive increase in blood levels of ascorbic acid (vitamin C) after exercise. This could indicate less oxidative stress on muscles. Further research is being conducted to determine the implications of this increase.
“This study is the latest in ASEA’s commitment to ongoing research. The frontiers of redox signaling molecules and ASEA are constantly being pushed. This latest study is not a destination, but an on-ramp,” said Verdis Norton, Chief Executive Officer at ASEA.
ASEA and Redox Signaling Molecules
ASEA, with its Redox Signaling technology, is a powerful new drink that helps both competitive and recreational athletes step up their game to new levels of performance.
ASEA is the original and only Redox Signaling product available today. It provides the body with two perfectly balanced sets of reactive molecules – the same molecules produced naturally by the mitochondria in every cell of the body. These vitally important molecules support the production of the ATP energy that fuels our cells, help activate antioxidants, minimize cellular damage, enhance cellular communication, and speed the healing response – all functions critical to athletic performance, endurance and recovery.
Redox Signaling is a burgeoning scientific field on a global scale with an impressive array of recent research advances. Only recently have ASEA scientists been able to produce stable mixtures of these Redox Signaling molecules outside living cells.
Athletic Reviews: Increased Performance, Endurance & Recovery
ASEA is used by these athletes to increase their competitive advantages. These athletes have all seen performance gains while drinking ASEA, especially quicker recovery times which allows them to get back to training sooner.
Human Performance Laboratory
The mission of the ASU/NCRC Human Performance Laboratory is to investigate the influence of unique plant molecules (e.g, flavonoids such as quercetin, luteolin, and epigallocatechin 3-gallate or EGCG) on age-related loss of muscle mass (sarcopenia), muscle mitochondrial biogenesis, and exercise-induced changes in immune function, oxidative stress, and inflammation.
The Human Performance Laboratory is located at Appalachian State University North Carolina Research Campus and is affiliated with the North Carolina Research Institute which brings together eight universities as well as researchers at Dole, General Foods and Monsanto.
The Company and Product
ASEA, LLC is a Salt Lake City-based company whose flagship product, also called ASEA, is the world’s first and only source of stable, balanced, native-to-the-body Redox Signaling molecules.
ASEA is sold in a 32-ounce bottle and an eight-ounce flexible pouch made from environmentally friendly materials. The 32-ounce bottle is made from a durable plastic. The eight-ounce flexible pouch fits easily into a backpack, pocket or in athletic gear. Both packages were created from input from competitive athletes and everyday ASEA consumers. The eight-ounce pouch includes a one-way valve to keep the pouch contents clean and pure. ASEA can be purchased through ASEA’s wide network of independent associates.
[These statements have not been evaluated by the Food and Drug Administration. The product is not intended to diagnose, treat, cure or prevent any disease.]
[The North Carolina Research Institute and its members, including Appalachian State University, do not endorse any products. The statements by NCRI scientists should not be construed as product promotion.]
The Emerging Field of Redox Signaling
Scientist Volumes of research from independent scientists around the world confirm the vital nature of Redox Signaling to cell health. And every day more research and published articles are appearing about Redox Signaling, making it one of the fastest growing research fields in science.
ASEA is the first and only stable, perfectly balanced mixture of these Redox Signaling reactive molecules that exists outside of living cells, and can be used to help maintain proper balance inside the body to support the immune system and healing process.
Redox Signaling Research Links:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.